Meta-omics Portal for Metabolic Dysfunction-Associated Steatotic Liver Disease
This portal integrates multi-cohort transcriptomic meta-analyses and genetic evidence for metabolic dysfunction-associated steatotic liver disease (MASLD). For any gene or pathway, it provides stage-resolved differential expression meta-analysis, gene/pathway–clinical correlation patterns, and complementary genetic evidence.
Fibrosis and MASLD progression are summarized using random-effects meta-analysis across multiple liver cohorts, visualized as study-level forest plots. Clinical radar panels quantify how genes and pathways correlate with metabolic and histological traits, while the genetics panel aggregates GWAS/TWAS/SMR/PWAS/PheWAS signals to help prioritize candidate genes for functional follow-up.
Citation
If you use the MASLD Portal in your research, please cite the accompanying study:
Feng, Z., Chen, F., Xiao, J., Du, A., Deng, J., Wu, S., Zhang, Y., Li, X., Zheng, A., & Li, H. (in press). Integrative multi-omics and multi-trait analysis prioritizes regulatory mechanisms and genes for metabolic dysfunction-associated steatotic liver disease. Cellular and Molecular Gastroenterology and Hepatology.